CBD Cannabidiol

Chemical formula: 2 - [(1R, 6R) -3- methyl-6- (prop-1- en-2-) cyclohex-2-enyl] -5- pentylbenzene-1,3- diol

Cannabidiol (CBD) is a metabolite of Cannabis sativa. It has sedative, hypnotic, anticonvulsant, antidistonic, antioxidant and anti-inflammatory effects. [1] It has also been shown to reduce intraocular pressure and is a promising atypical antipsychotic.

Property
CBD enhances the analgesic efficacy of THC by prolonging its duration of action (activating the serotoninergic pathway at the dorsal raphe level) and at the same time reducing its side effects on heart rate, respiration and body temperature. In particular, CBD interacts as an agonist towards the cannabinoid receptors GPR55, towards the vanilloid receptors TRPV1 and TRPV2 and towards the receptors for serotonin 5-HT1a. Cannabidiol is also a non-specific antagonist of the CB1 and CB2 cannabinoid receptors, of the MOR and DOR opioid receptors and of other neurotransmitters.

Therapeutic use
According to a laboratory research carried out in 2007 by a team from the California Pacific Medical Center Research Institute, [2] cannabidiol may be able to block the Id-1 gene that causes the spread of breast cancer metastasis, but also of other tumour forms. A more recent study conducted by the University of Rostock in Germany would confirm similar properties of cannabinoids and in particular of the metabolite called cannabidiol combined with THC, the active ingredient. Professor Burkhard Hinz, who coordinated the research, said that "although we are still far from putting our discovery into practice in clinical therapy, what emerges is that cannabidiol and THC have potentially therapeutically useful effects in the fight against cancer ». In fact, both would contribute to the destruction of cancer cells by stimulating the formation of a specific protein, ICAM-1, able to act on the surface of cells attacked by the tumour.